Cell-dependent susceptibility to Porcine circovirus ORF3-induced apoptosis

Porcine circovirus associated disease (PCVAD) has caused considerable economic impact worldwide since its first description on a Canadian pig farm in the 1990s. PCVAD, a wasting and immunosuppressive disease in post-weaned pigs, is caused by Porcine circovirus type 2 (PCV2). Despite the availability of effective vaccines, little is known about the molecular pathogenesis of the disease. Belonging to the Circoviridae family, PCV2 and PCV1 are closely-related viruses with a 1.7kb, ambisensed and c