Marbofloxacin achieves high concentration in pig tonsils according to a dose dependent fashion

Actinobacillus pleuropneumonaie (APP) is the causative agent of porcine pleuropneumonia. Pigs can become asymptomatic carriers of the organism in their tonsils for long periods. Attempts to eradicate APP from pig herds have been made with antibiotics but there is a paucity of information about the penetration of antibiotics in tonsils. Marbofloxacin (MB) is a fluoroquinolone widely used in veterinary medicine to control APP under field conditions. The goal of this study was to quantify the MB p