The medical doctors have faced a number of resistance epidemics such as methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum beta lactamase (ESBL) producing bacteria such as Escherichia coli. Carbapenems are also beta-lactam antibiotics used almost as a last resort in human medicine, when 3rd and 4th generation cephalosporins are failing, so the development of resistance in bacteria by the production of enzymes that breaks down carbapenems (carbapenemases) is a very serious if
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